Lethal Weapon: Cast Lethal Weapon Drama, Crime, Action 9/21/16 – 2/26/19 United States http://www.fox.com/lethal-weapon GeneralEpisodesCastCharactersGallery Cast See full cast → Damon Wayans as Detective Roger Mayfield Murtaugh Keesha Sharp as Trish Murtaugh Kevin Rahm as Captain Brooks Avery Michelle Mitchenor as Detective Sonya Bailey Johnathan Fernandez as Scorsese Clayne Crawford as Detective Martin Riggs Chandler Kinney as Riana Murtaugh Jordana Brewster as Dr. Maureen "Mo" Cahill Dante Brown as Roger Murtaugh, Jr. Seann William Scott as Wesley Cole