Samantha Who?: Cast Rate: –☹️ Very Bad🙁 Bad😐 Average🙂 Good😃 Excellent🤩 Super! ★ Save Rating✔ Rating Saved! Notify me: –about new episodeabout new seasonabout end of season Subscribe✔ Subscription Saved! Samantha Who? Comedy – 7/23/09 United States GeneralEpisodesCastCharactersGallery Cast See full cast → Christina Applegate as Samantha "Sam" Newly Jean Smart as Regina Newly Jean Smart as Regina Newly Jennifer Esposito as Andrea Belladonna Jennifer Esposito as Andrea Belladonna Melissa McCarthy as Dena Melissa McCarthy as Dena Barry Watson as Todd Deepler Barry Watson as Todd Deepler Kevin Dunn as Howard Newly Kevin Dunn as Howard Newly Tim Russ as Frank Tim Russ as Frank Christina Applegate as Samantha Kevin Dunn as Howard Barry Watson as Todd Rick Hoffman as Chase Chapman Stephen Rannazzisi as Seth Billy Zane as Winston Funk Kiele Sanchez as Chloe Joy Osmanski as Tracy James Tupper as Owen McKinley Freeman as Tony Dane Arshad Aslam as Barista
